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The mechanistic story emphasizes neurotransmitter system normalization rather than direct receptor agonism

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You should consider a more advanced intervention if: Pain is progressively worsening despite appropriate treatment You develop a new or worsening weakness in your hand Symptoms significantly impact your ability to work or perform daily activities Youve completed 12 weeks of thorough conservative care without adequate improvement You experience bowel or bladder dysfunction (immediate surgical emergency) Surgical Options: Traditional Approaches vs